Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1,441 – 1,455 of 5,523 results

1,441

Apexbio Technology LLC ITF2357 (Givinostat) 732302-99-7 200mg

ITF2357 (Givinostat CAS 732302-99-7) is a small molecule inhibitor targeting class I and II histone deacetylases (HDAC) It suppresses hematopoietic colony formation driven by JAK2V617F mutation in chronic myeloproliferative neoplasms Mechanistically ITF2357 induces apoptosis in multiple myeloma (MM) and acute myeloid leukemia (AML) by elevating p21 expression and simultaneously reducing anti-apoptotic proteins Bcl-2 and Mcl-1 Additionally ITF2357 diminishes inflammatory cytokines (IL-1 IL-6 TNF- and IFN- ) in peripheral blood mononuclear cells and inhibits production of IL-6 and VEGF in mesenchymal stromal cells reflecting potential therapeutic applications in cancer research and inflammation regulation

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1,442

Apexbio Technology LLC Cyclophosphamide 50-18-0 200mg

Cyclophosphamide is a nitrogen mustard alkylating prodrug activated via hepatic enzymes to its active metabolites These metabolites alkylate DNA primarily at guanine residues resulting in DNA cross-linking strand breaks and mutations consequently triggering cytotoxic effects Cyclophosphamide exhibits cytotoxicity in vitro with an IC50 of 37 6 M in mouse embryo BALB/c 3T3 cells and an IC50 of 8 79 M against human HL60 cells It impacts immune regulation by decreasing regulatory T cell counts and suppressive marker expression (FoxP3 GITR) facilitating immune response modulation Commonly applied in cancer and immunological research cyclophosphamide is also employed in genotoxicity assays due to its capacity to induce chromosomal aberrations and mutations

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1,443

Apexbio Technology LLC LY2603618 911222-45-2 200mg

LY2603618 (CAS 911222-45-2) is a small-molecule inhibitor selectively targeting checkpoint kinase 1 (Chk1) an enzyme responsible for orchestrating DNA damage repair pathways It competitively binds Chk1 s ATP-binding domain thereby inhibiting its kinase activity Experimental studies in non-small cell lung cancer cell lines (including A549 and H1299) demonstrated that treatment with LY2603618 induced DNA damage increased -H2AX phosphorylation and resulted in G2/M phase cell cycle arrest In vivo assessments using Calu-6 lung cancer xenograft models indicated enhanced DNA damage response when combined with gemcitabine chemotherapy LY2603618 is employed as a valuable tool in cancer research to explore Chk1 s biological role and evaluate synergistic therapeutic strategies

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1,444

APEXBIO TECHNOLOGY LLC Oxaliplatin 61825-94-3 200mg

Oxaliplatin (CAS 61825-94-3) is a platinum-based chemotherapeutic agent that functions primarily by forming DNA adducts thereby disrupting DNA synthesis and ultimately inducing apoptosis via primary and secondary DNA damage It demonstrates antitumor activity against various cancer cell lines including melanoma (IC50 0 14 7 85 M) ovarian carcinoma (IC50 0 17 M) bladder cancer (IC50 11 15 M) colon cancer (IC50 2 95 M) and glioblastoma (IC50 17 6 30 9 M) Oxaliplatin is useful in preclinical animal tumor models and has clinical applications notably in metastatic colorectal cancer therapy combined with fluorouracil and folinic acid

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1,445

Apexbio Technology LLC Evacetrapib (LY2484595) 1186486-62-3 200mg

Evacetrapib (LY2484595 CAS 1186486-62-3) is a potent and selective inhibitor targeting cholesteryl ester transfer protein (CETP) a regulator of lipid metabolism Evacetrapib exhibits inhibitory activity with IC50 values of 5 5 nM in assays containing recombinant human CETP and 26 nM within human plasma CETP assays In vivo oral administration at 30 mg/kg in human CETP/ApoAI double-transgenic mice significantly reduces CETP activity and elevates HDL-cholesterol concentration (ED50 5 mg/kg) Evacetrapib does not elevate blood pressure nor induce aldosterone or cortisol synthesis in model systems highlighting its potential in cardiovascular research related to coronary artery disease

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1,446

Apexbio Technology LLC BGJ398(Synonyms: Infigratinib, NVP-BGJ398, BGJ-398, BGJ 398), 200mg, CAS: 872511-34-7.

BGJ398 (CAS 872511-34-7) also known as NVP-BGJ398 is an orally bioavailable small-molecule inhibitor targeting fibroblast growth factor receptors (FGFRs) It selectively inhibits receptor tyrosine kinase activity of FGFR1 FGFR2 FGFR3 and FGFR4 which are critical mediators in signal transduction pathways involved in cell proliferation differentiation and survival In preclinical studies BGJ398 suppresses proliferation and induces apoptosis in FGFR-dependent cancer cells additionally it demonstrates antitumor activity in xenograft tumor models BGJ398 is utilized as a research tool in oncology studies investigating FGFR-driven malignancies

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1,447

Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 10mg, CAS: 130370-60-4.

Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development

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1,448

Apexbio Technology LLC Molnupiravir(Synonyms: EIDD-2801, MK-4482, Lagevrio, Molnupex, EIDD-1931-isopropyl ester, EIDD-2801 prodrug), 200mg, CAS: 2349386-89-4.

Molnupiravir (CAS 2349386-89-4) is an orally bioavailable nucleoside analog prodrug metabolized intracellularly into an active nucleoside triphosphate derivative Its antiviral effect occurs once incorporated by viral RNA-dependent RNA polymerase into newly synthesized viral RNA inducing an accumulation of mutations that disrupt viral genome fidelity and replication In research applications Molnupiravir is extensively employed for in vitro and in vivo studies investigating antiviral activities replication mechanisms and pharmacological responses especially against RNA viruses such as SARS-CoV-2 influenza virus and other coronaviruses

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1,449

Apexbio Technology LLC Matrine(Synonyms: Sophocarpidine, Matridin, (-)-Matrine, α-Matrine, (−)-α-Matrine, L-Matrine, Kushenin), 200mg, CAS: 519-02-8.

Matrine (CAS 519-02-8) is an alkaloid derived from plants in the Sophora genus with demonstrated anticancer and anti-inflammatory activities It functions in part through agonism of kappa-opioid and possibly other receptors Matrine inhibits the MNK45 gastric cancer cell line proliferation (IC50 540 g/ml MTT assay) by modifying protein expression profiles (e g NF- B XIAP CIAP p-ERK) In vitro matrine induces apoptosis in NSCLC cells through ROS generation caspase activation and p38 pathway modulation Animal studies suggest therapeutic roles in cardiac injury and sepsis-related lung inflammation

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1,450

Apexbio Technology LLC Propidium iodide(Synonyms: PI, Propidium iodide solution, PI staining reagent, Propidium iodide nuclear stain), 10mg, CAS: 25535-16-4.

Propidium iodide (CAS 25535-16-4) commonly abbreviated as PI is a fluorescent nucleic acid intercalating dye widely employed in biomedical research Structurally analogous to ethidium bromide PI intercalates into double-stranded DNA molecules without sequence specificity binding approximately one dye per 4 5 base pairs Due to membrane impermeability PI selectively enters cells only when plasma membrane integrity is compromised as occurs during cell death or late apoptosis Upon DNA binding its fluorescence notably increases facilitating detection via fluorescence microscopy spectrometry or flow cytometry PI is routinely utilized for distinguishing necrotic or late apoptotic cells in viability assays apoptosis studies (often paired with Annexin V) and cell cycle analyses

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1,451

APEXBIO TECHNOLOGY LLC Pomalidomide (CC-4047) 19171-19-8 200mg

Pomalidomide (CC-4047) an immunomodulatory derivative structurally related to Thalidomide exhibits anti-tumor and anti-angiogenic properties Chemically the molecule is distinguished by additional amino substituent at the fourth position of the phthalimide ring and two extra oxy groups Its mechanism of action includes modulation of specific cytokines within the tumor microenvironment (TNF- IL-6 IL-8 VEGF) suppression of tumor cell proliferation and modification of host immune cell activity Pomalidomide is widely studied in biomedical research particularly in therapeutic exploration for hematologic malignancies such as multiple myeloma including relapsed or refractory disease states

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1,452

APEXBIO TECHNOLOGY LLC Ciprofibrate 52214-84-3 200mg

Ciprofibrate is a selective agonist targeting peroxisome proliferator-activated receptor alpha (PPAR ) a nuclear receptor involved in regulating lipid metabolism and energy homeostasis Its activation promotes gene expression linked to fatty acid oxidation triglyceride reduction and cholesterol metabolism Ciprofibrate is frequently applied as a molecular tool in biomedical research to investigate mechanisms underlying dyslipidemia atherosclerosis and metabolic-related disorders Additionally due to its receptor-specific mode of action it serves as a standard experimental reference in in vitro assays and animal models assessing lipid-lowering therapeutic strategies and PPAR -dependent signaling pathways

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1,453

Apexbio Technology LLC Dihydroethidium(Synonyms: Hydroethidine, DHE, HE, Dihydroethidine, Ethidium hydride), 10mg, CAS: 104821-25-2.

Dihydroethidium (CAS 104821-25-2) also known as hydroethidine is a cell-permeable fluorescent probe widely utilized for detecting superoxide anions (O ) in live cells After entering cells dihydroethidium is oxidized by intracellular superoxide anions to ethidium which subsequently intercalates into DNA emitting detectable red fluorescence (excitation/emission 518/605 nm) Unoxidized dihydroethidium exhibits blue fluorescence (355/420 nm) The intensity of the red fluorescence correlates directly with intracellular O concentration Thus dihydroethidium serves as a valuable tool in evaluating oxidative stress and studying associated physiological/pathological processes including apoptosis cell proliferation cardiovascular pathologies diabetes and cancer

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1,454

Apexbio Technology LLC Dihydroethidium(Synonyms: Hydroethidine, DHE, HE, Dihydroethidine, Ethidium hydride), 25mg, CAS: 104821-25-2.

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1,455

Apexbio Technology LLC Nicotinamide Riboside Chloride (NIAGEN)(Synonyms: NR Chloride, Niagen, Nicotinamide Riboside Chloride, NR-Cl, Nicotinamide Riboside Cl), 200mg, CAS: 23111-00-4.

Nicotinamide Riboside Chloride (NIAGEN CAS 23111-00-4) is a small molecule precursor of nicotinamide adenine dinucleotide (NAD ) an essential cofactor implicated in energy metabolism and cellular homeostasis Upon oral administration it effectively elevates intracellular NAD levels subsequently modulating the activity of NAD -dependent sirtuin enzymes particularly SIRT1 and SIRT3 Experimental evidence indicates that Nicotinamide Riboside Chloride enhances oxidative metabolism and mitigates metabolic dysfunction induced by high-fat dietary conditions Additionally studies employing Alzheimer s disease transgenic mouse models suggest that this compound can reduce cognitive decline supporting its use in biomedical research targeting metabolic and neurodegenerative conditions

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Quinolines and derivatives

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